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nevus sebaceous (organoid nevus)

Congenital malformation of sebaceous gland differentiation on the scalp or rarely on the face. Pathology: - papillomatous epidermal hyperplasia with large numbers of mature sebaceous glands (case report of cerebroform nevus sebaceous) [2] - may be part of a complex syndrome that includes skeletal, ocular, & neurologic abnormalities [2] - risk of malignant transformation (basal cell carcinoma) [2] Genetics: - mosaic genetic mutations in the HRAS & KRAS genes Clinical manifestations: - hairless, thin, elevated 1-2 cm plaque orange in color Complications: 10% of patients develop basal cell carcinoma Management: - surgical excision timed around & prior to puberty for cosmetic reasons & to prevent development of basal cell carcinoma [1,2]

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nevus

References

  1. Color Atlas & Synopsis of Clinical Dermatology, Common & Serious Diseases, 3rd ed, Fitzpatrick et al, McGraw Hill, NY, 1997, pg 179
  2. Lee JD, Kim HS IMAGES IN CLINICAL MEDICINE. Cerebriform Nevus Sebaceous. N Engl J Med 2015; 373:262. July 16, 2015 PMID: 26176383 http://www.nejm.org/doi/full/10.1056/NEJMicm1412178

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