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neuroprotectin D1 (NPD1)
Neuroprotective agent formed via lipoxygenase-mediated metabolism of docosahexaenoic acid.
Related
4,7,10,13,16,19-docosahexaenoic acid [C22:6w3]; cervonic acid (DHA, Doconexent)
General
5-lipoxygenase metabolite
neuroprotectin
Properties
COMPARTMENT: membrane
SECRETED-BY: neutrophil
macrophage
mast cell
References
- Lukiw WJ, Cui JG, Marcheselli VL, Bodker M, Botkjaer A,
Gotlinger K, Serhan CN, Bazan NG.
A role for docosahexaenoic acid-derived neuroprotectin D1 in
neural cell survival and Alzheimer disease.
J Clin Invest. 2005 Oct;115(10):2774-83.
PMID: 16151530
- Bazan NG.
Neuroprotectin D1 (NPD1): a DHA-derived mediator that protects
brain and retina against cell injury-induced oxidative stress.
Brain Pathol. 2005 Apr;15(2):159-66. Review.
PMID: 15912889
- Mukherjee PK, Marcheselli VL, Serhan CN, Bazan NG.
Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene
protects human retinal pigment epithelial cells from oxidative
stress.
Proc Natl Acad Sci U S A. 2004 Jun 1;101(22):8491-6.
Epub 2004 May 19.
PMID: 15152078