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neuropil threads
Structure:
- contain paired helical filaments with hyperphosphorylated (PHF) tau
Pathology:
- occur in axons & dendrites
- seen in
- Alzheimer's disease - most prominant in select subfields & layers of ventromedial temporal lobe & association cortex
- corticobasal degeneration
- progressive supranuclear palsy
- frontotemporal dementia with parkinsonism
General
abnormal morphologic structure (malformation)
References
- Mitchell TW, Nissanov J, Han LY et al.
J Histochem Cytochem. 2000 Dec;48(12):1627-38.
Novel method to quantify neuropil threads in brains from elders with or without
cognitive impairment.
PMID: 11101631