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neuron-specific enolase in serum
Specimen:
1) serum
2) stable up to 48 hours at 2-8 degrees C
3) freeze at -20 degrees C for longer periods
4) avoid repeated freeze-thaw cycles
5) avoid hemolysis
6) separated serum from erythrocytes in < 60 minutes
Reference values:
1) 0-9 ng/mL (Pharm)
2) 0-22 ng/mL (Roche)
Interferences:
-> neuron-specific enolase (enolase-2) is also found in:
1) erythrocytes
2) plasma cells
3) platelets
Increases:
-> clinical disorders
1) neuroendocrine tumors of APUD origin
a) 90-100% of patients with neuroblastoma
b) small cell carcinoma of the lung
1] 50-90% of patients
2] enzyme activity correlates with extent of disease
c) retinoblastoma
d) medullary carcinoma of the thyroid
e) pancreatic islet cell carcinoma
f) carcinoid
g) pheochromocytoma
2) septic shock
3) pneumonia
4) neural trauma
Related
enolase-2; gamma-enolase; neuron specific enolase (ENO2)
General
neuron specific enolase in body fluid
References
- Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed.,
W.B. Saunders, 1995
- Neuron Specific Enolase
Laboratory Test Directory ARUP: 98198