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neurofilament light chain in CSF
Indications:
- marker for axonal damage [1]
Clinical significance:
- CSF levels associated with neurodegenerative disease & cognitive decline [1]
- highest levels in patients with amyotrophic lateral sclerosis & frontotemporal dementia [1]
- increases in CSF p-tau & CSF NFL in patients with Down syndrome in 4th decade of life [2]
Related
neurofilament light polypeptide; NF-L; neurofilament triplet L protein; 68 kD neurofilament protein (NEFL, NF68, NFL)
General
neurofilament light chain in body fluid
References
- Olsson B, Portelius E, Cullen NC et al
Association of Cerebrospinal Fluid Neurofilament Light Protein
Levels With Cognition in Patients With Dementia, Motor Neuron
Disease, and Movement Disorders.
JAMA Neurol. 2018 Dec 3.
PMID: 30508027
https://jamanetwork.com/journals/jamaneurology/fullarticle/2716834
- Clinical and biomarker changes of Alzheimer's disease in adults
with Down syndrome: A cross-sectional study.
Lancet 2020 Jun 27; 395:1988.
PMID: 32593336 Free PMC article
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30689-9/fulltext
- Head E, Ances B.
Biomarkers in Down syndrome can help us understand Alzheimer's disease.
Lancet 2020 Jun 27; 395:1951
PMID: 32593327
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30916-8/fulltext