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neurofilament
Function:
- neurofilaments may form from neurofilament L & either neurofilament M or neurofilament H
- neurofilaments within perikarya & proximal dendrites are normally minimally phorphorylated
- in contrast, neurofilaments in axons are normally heavily phosphorylated
Structure:
- cytoskeletal filaments:
- microtubules: 25 nm
- intermediate filaments: 10-12 nm (includes neurofilaments)
- microfilaments: 7-10 nm
Related
neurofilament Ag in tissue
neurofilament disorder
General
intermediate filament
Properties
COMPARTMENT: cytoplasm
CELL-REGION: neurite
CELL: neuron
SUBUNITS: neurofilament protein
MOTIF: O-glycosylation site {N-TERMINAL}
rod-like {central-region}
MOTIF: alpha helix
coiled coil
glutamate-rich region {C-TERMINAL}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site (SEVERAL)
MOTIF-SEQUENCE: KSP
References
Cairns NJ, Lee VM, Trojanowski JQ.
The cytoskeleton in neurodegenerative diseases.
J Pathol. 2004 Nov;204(4):438-49. Review.
PMID: 15495240
Components
neurofilament protein