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protein neurobeachin; lysosomal-trafficking regulator 2; protein; BCL8 (NBEA, BCL8B, KIAA1544, LYST2)
Function:
1) binds to PKA2 regulatory subunits, anchors/targets them to membrane
2) may anchor PKA2 to cytoskeletal &/or organelle-associated proteins
Structure:
- PKA2 regulatory subunit binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the PKA2 regulatory subunit dimer (putative)
- belongs to the WD repeat neurobeachin family
- contains 1 BEACH domain
- contains 5 WD repeats
Compartment: cytoplasm, peripheral membrane
Alternative splicing: named isoforms=2
Expression:
- expressed in brain > spleen, thymus, prostate, testis, ovary > heart, kidney, pancreas, skeletal muscle, intestine
Related
lysosomal-trafficking regulator; Beige homolog (LYST, CHS, CHS1)
General
human longevity protein
WD repeat protein family
Properties
SIZE: MW = 328 kD
entity length = 2946 aa
MOTIF: WD repeat {1326-1368}
beach domain {2274-2563}
WD repeat {2718-2761}
WD repeat {2778-2818}
WD repeat {2860-2899}
WD repeat {2902-2941}
Database Correlations
OMIM 604889
UniProt Q8NFP9
PFAM correlations
Entrez Gene 26960
Kegg hsa:26960
References
UniProt :accession Q8NFP9