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neurexin-1-alpha; neurexin I-alpha (NRXN1, KIAA0578)
Function:
- neuronal cell surface protein
- may be involved in cell recognition & cell adhesion
- may mediate intracellular signaling
- specific isoforms bind to alpha-dystroglycan & to alpha-latroxin
- cytoplasmic C-terminal region binds to CASK, CASKIN1 & APBA1
- interacts with SYT13 & SYTL1 (putative)
Structure:
- N-glycosylated & O-glycosylated (putative)
- the laminin G-like domain 2 binds to NXPH1
- belongs to the neurexin family
- contains 3 EGF-like domains
- contains 6 laminin G-like domains
Compartment: membrane Alternative promoter: yes
Alternative splicing: named isoforms=2
Expression:
- heart & brain
- expressed in all brain regions
- highest levels in the claustrum & thalamic nuclei [3]
General
neurexin-1
Properties
SIZE: entity length = 1477 aa
MW = 162 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-30}
Laminin G-like {31-217}
MOTIF: N-glycosylation site {N125}
N-glycosylation site {N190}
EGF domain {213-256}
MOTIF: cysteine residue {C228}
MODIFICATION: cysteine residue {C243}
cysteine residue {C243}
MODIFICATION: cysteine residue {C228}
cysteine residue {C245}
MODIFICATION: cysteine residue {C255}
cysteine residue {C255}
MODIFICATION: cysteine residue {C245}
Laminin G-like {283-473}
MOTIF: Ca+2-binding site
SITE: 329-329
Ca+2-binding site
SITE: 346-346
Ca+2-binding site
SITE: 407-407
cysteine residue {C437}
MODIFICATION: cysteine residue {C473}
cysteine residue {C473}
MODIFICATION: cysteine residue {C437}
Laminin G-like {480-672}
MOTIF: cysteine residue {C643}
MODIFICATION: cysteine residue {C672}
cysteine residue {C672}
MODIFICATION: cysteine residue {C643}
EGF domain {676-713}
MOTIF: cysteine residue {C680}
MODIFICATION: cysteine residue {C691}
cysteine residue {C685}
MODIFICATION: cysteine residue {C700}
cysteine residue {C691}
MODIFICATION: cysteine residue {C680}
cysteine residue {C700}
MODIFICATION: cysteine residue {C685}
cysteine residue {C702}
MODIFICATION: cysteine residue {C712}
cysteine residue {C712}
MODIFICATION: cysteine residue {C702}
Laminin G-like {718-891}
MOTIF: N-glycosylation site {N790}
Laminin G-like {905-1080}
MOTIF: cysteine residue {C1052}
MODIFICATION: cysteine residue {C1080}
cysteine residue {C1080}
MODIFICATION: cysteine residue {C1052}
EGF domain {1083-1120}
MOTIF: cysteine residue {C1087}
MODIFICATION: cysteine residue {C1098}
cysteine residue {C1092}
MODIFICATION: cysteine residue {C1107}
cysteine residue {C1098}
MODIFICATION: cysteine residue {C1087}
cysteine residue {C1107}
MODIFICATION: cysteine residue {C1092}
cysteine residue {C1109}
MODIFICATION: cysteine residue {C1119}
cysteine residue {C1119}
MODIFICATION: cysteine residue {C1109}
Laminin G-like {1126-1294}
MOTIF: N-glycosylation site {N1223}
threonine-rich region {1324-1327}
MOTIF: threonine residue (SEVERAL)
transmembrane domain {1402-1422}
MOTIF: alanine-rich region {1409-1412}
MOTIF: alanine residue (SEVERAL)
Database Correlations
OMIM 600565
UniProt Q9ULB1
PFAM correlations
Entrez Gene 9378
References
- Ushkaryov YA et al
Neurexins: synaptic cell surface proteins related to the
alpha-latrotoxin receptor and laminin.
Science 257:50 1992
PMID: 1621094
- Hata Y et al
Interaction of synaptotagmin with the cytoplasmic domains of
neurexins.
Neuron 10:307 1993
PMID: 8439414
- Ullrich B et al
Cartography of neurexins: more than 1000 isoforms generated by
alternative splicing and expressed in distinct subsets of
neurons.
Neuron 14:497 1995
PMID: 7695896
- UniProt :accession Q9ULB1