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nestin (NES)
Function:
- intermediate filament protein expressed in CNS stem cells in neural tube
- later replaced by neurofilament upon terminal differentiation
- may play a role in the trafficking & distribution of intermediate filament proteins & potentially other cellular factors to daughter cells during progenitor cell division (putative)
- interacts with FHOD3 (putative)
Structure: belongs to the intermediate filament family
Expression:
- CNS stem cells
- immature skeletal muscle cells
- upon terminal neural differentiation, nestin is down-regulated & replaced by neurofilaments
Pathology:
- expressed in:
- primitive neuroectodermal tumors [2]
- rhabdomyosarcoma [1]
- medulloblastoma [3]
- astrocytoma [3]
- glioblastoma [3]
- ependymoma [3]
- ganglioglioma [3]
- meningioma [3]
General
intermediate filament protein
phosphoprotein
Properties
SIZE: entity length = 1621 aa
MW = 177 kD
COMPARTMENT: cytoplasm
MOTIF: Head {1-7}
Rod {8-313}
MOTIF: Coil 1A {8-43}
Linker 1 {44-55}
Coil 1B {56-151}
Linker 12 {152-173}
Coil 2A {174-192}
Linker 2 {193-195}
Coil 2B {196-313}
Ser phosphorylation site {S311}
Tail {314-1621}
MOTIF: Thr phosphorylation site {T315}
Ser phosphorylation site {S320}
Ser phosphorylation site {S325}
Thr phosphorylation site {T338}
Thr phosphorylation site {T354}
Thr phosphorylation site {T384}
Thr phosphorylation site {T388}
Ser phosphorylation site {S398}
Ser phosphorylation site {S471}
Ser phosphorylation site {S548}
Ser phosphorylation site {S564}
Ser phosphorylation site {S578}
Ser phosphorylation site {S588}
Ser phosphorylation site {S680}
Ser phosphorylation site {S746}
Ser phosphorylation site {S768}
Ser phosphorylation site {S842}
Thr phosphorylation site {T851}
Ser phosphorylation site {S905}
Ser phosphorylation site {S1286}
Ser phosphorylation site {S1409}
Ser phosphorylation site {S1418}
Ser phosphorylation site {S1585}
Ser phosphorylation site {S1615}
Ser phosphorylation site {S1617}
Ser phosphorylation site {S1618}
Database Correlations
OMIM 600915
UniProt P48681
Pfam PF00038
Entrez Gene 10763
Kegg hsa:10763
References
- OMIM :accession 600915
- Zhu Y & Parada LF
The molecular and genetic basis of neurological tumours
Nature Reviews Cancer 2:616-26, 2002
PMID: 12154354
- WHO Classification Tumours of the Nervous System.
Kleihues & Cavenee eds. IARC Press 2000
- UniProt :accession P48681