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Nesprin-3 (SYNE3, C14orf49)
Function:
- role in the maintenance of nuclear organization & structural integrity
- probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC1/Plectin which can associate with the intermediate filament system
- interacts with actin-binding domain of PLEC1/plectin
Structure:
- belongs to the nesprin family
- contains 1 KASH domain
- contains 2 spectrin repeats
Compartment:
- nucleus outer membrane
- located at the rough endoplasmic reticulum in some cells
Alternative splicing: named isoforms=3
General
membrane protein
Properties
SIZE: MW = 112 kD
entity length = 975 aa
COMPARTMENT: cell nucleus
MOTIF: Spectrin {220-325}
coiled coil {617-645}
Spectrin {647-740}
KASH {917-975}
MOTIF: transmembrane domain {926-946}
Perinuclear space {947-975}
Database Correlations
UniProt Q6ZMZ3
References
UniProt :accession Q6ZMZ3