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neonatal diabetes mellitus
Epidemiology:
- rare
Genetics:
- defects in ABCC8 are the cause of transient neonatal diabetes mellitus type 3
- defects in KCNJ11 are the cause of transient neonatal diabetes mellitus type 3
Clinical manifestations:
- insulin-requiring hyperglycemia within the 1st month of life
- in about half of the neonates, diabetes is transient & resolves at a median age of 3 months, whereas the rest have a permanent form of diabetes
Laboratory:
- KCNJ11 gene mutation
Complications:
- possible relapse during adolescence
- possible increased risk of diabetes type 2 later in life
- gestational diabetes
Specific
permanent neonatal diabetes mellitus (PNDM); permanent diabetes mellitus of infancy (PDMI)
General
diabetes mellitus type 1 (insulin-dependent, juvenile)
neonatal disorder or disease
Database Correlations
OMIM correlations
References
UniProt :accession Q14654