Search
neomycin (Mycifradin)
Tradename: Mycifradin.
Indications:
- surgical prophylaxis for colorectal procedures (generally in combination with erythromycin)
- bowel preparation [4]
- adjunctive agent in the treatment of hepatic encephalopathy
- otitis externa [4]
- skin infections [4]
Dosage:
1) hepatic encephalopathy:
a) adults: 4-12 g/day PO divided every 4 hours, or 500-2000 mg every 6-8 hours
b) pediatrics: 50-100 mg/kg/day divided every 4-6 h for 5-6 days, not to exceed 12 g/day
2) preoperative intestinal antisepsis
a) adults:
-> 1 g hourly for 4 doses, then 1 g every 4 hours for 5 doses, or 1 g at 1 PM, 2PM & 11 PM the day prior to surgery in combination with erythromycin
b) children:
-> 90 mg/kg/day divided every 4 hours for 2 days, or 25 mg/kg at 1 PM, 2 PM & 11 PM on the day prior to surgery in combination with erythromycin
Tabs: 500 mg.
Solution: 125 mg/5 mL.
Topical antibiotic.
Pharmacokinetics:
1) only 3% of dose is absorbed from GI tract
2) high concentrations achieved in the bowel & feces
3) most is eliminated in the feces
4) 1/2life is 2-3 hours
Adverse effects:
1) not common (1-10%)
- contact dermatitis, burning, erythema, rash, urticaria, contact conjunctivitis
2) uncommon (< 1%)
- nausea/vomiting, diarrhea, neuromuscular blockage, ototoxicity, nephrotoxicity
Drug interactions:
- neomycin may decrease absorption of warfarin
Mechanism of action: inhibition of bacterial protein synthesis
Interactions
drug interactions
drug adverse effects of aminoglycosides
General
aminoglycoside antibiotic
Properties
MISC-INFO: elimination route FECES
pregnancy-category D
safety in lactation ?
elimination by hemodialysis +
Database Correlations
PUBCHEM correlations
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Drug Information & Medication Formulary, Veterans Affairs,
Central California Health Care System, 1st ed., Ravnan et al
eds, 1998
- Kaiser Permanente Northern California Regional Drug
Formulary, 1998
- Deprecated Reference
- Sasseville D
Neomycin
Dermatitis. 2010 Jan-Feb;21(1):3-7.
PMID: 20137735
Component-of
bacitracin/cortisol/neomycin/polymixin b
bacitracin/lidocaine/neomycin
bacitracin/lidocaine/neomycin/polymixin b
bacitracin/neomycin
bacitracin/neomycin/polymixin b/pramoxine
bacitracin/neomycin/polymixin-B (Neosporin)
colistin/cortisol/neomycin (Coly-Mycin S)
colistin/cortisol/neomycin/thonzonium bromide
cortisol/neomycin
cortisol/neomycin/polymixin-B (Corticosporin, Cortisporin, Cortomycin)
cortisol/neomycin/polymyxin B
dexamethasone/neomycin (NeoDecadron)
dexamethasone/neomycin/polymixin-B (Maxitrol, Dexasporin)
dexamethasone/neomycin/thiabendazole
fluocinolone/neomycin (Neo-Synalar)
gramicidin/neomycin/polymixin-B (Opthneosporin, AK-spore)
isoflupredone/neomycin/tetracaine
neomycin/nystatin/thiostrepton/triamcinolone
Neomycin/Polymixin B (Neosporin GU irrigant)
neomycin/polymixin B/pramoxine
neomycin/polymixin b/prednisolone