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serine/threonine protein kinase Nek8; never in mitosis A-related kinase 8; NimA-related protein kinase 8; Nima-related protein kinase 12a (NEK8, JCK, NEK12A)
Function:
- required for renal tubular integrity
- may regulate local cytoskeletal structure in renal tubule epithelial cells
- may regulate ciliary biogenesis through targeting of proteins to the cilia (putative)
- interacts with PKD2
- may regulate PKD2 targeting to the cilium (putative)
Cofactor: Mg+2 (putative)
Structure:
- belongs to the protein kinase superfamily, NEK Ser/Thr protein kinase family, NIMA subfamily
- contains 1 protein kinase domain
- contains 5 RCC1 repeats
Compartment:
- cytoplasm (putative)
- cytoskeleton, cell projection, cilium (putative)
- predominantly cytoplasmic
- localizes to the proximal region of the primary cilium & is not observed in dividing cells
Expression:
- highest expression in thyroid, adrenal gland & skin
- low levels in spleen, colon & uterus
Pathology:
- overexpressed in breast tumors
- highest expression in infiltrating ductal carcinomas
- moderate levels in mucinous adenocarcinoma
- defects in NEK8 are the cause of nephronophthisis type 9
General
serine/threonine protein kinase NEK (never in mitosis gene A-related kinase, NimA-related protein kinase, NimA-like protein kinase)
Properties
SIZE: entity length = 692 aa
MW = 75 kD
COMPARTMENT: cytoplasm
STATE: active state
MOTIF: kinase domain
SITE: 4-258
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 10-18
ATP-binding site
NAME: ATP-binding site
SITE: 33-33
aspartate residue {D128}
Thr phosphorylation site {T162}
RCC1 repeat {312-350}
RCC1 repeat {410-461}
RCC1 repeat {462-513}
RCC1 repeat {580-631}
RCC1 repeat {632-684}
Database Correlations
OMIM correlations
MORBIDMAP 609799
UniProt Q86SG6
PFAM correlations
Entrez Gene 284086
Kegg hsa:284086
ENZYME 2.7.11.1
References
UniProt :accession Q86SG6