Contents

Search

neddylation

Conjugation of a target protein with ubiquitin-like protein NEDD8. The only known substrates for neddylation by NEDD8 are the cullins. Neddylation of cullins plays a role in recruitment of ubiquitin-conjugating protein-E2 to the multienzymatic ubiquitination complex. Neddylation may play a role in: 1) cell cycle regulation 2) cytoskeletal regulation

Related

NEDD8; ubiquitin-like protein Nedd8; neddylin; neural cell expressed developmentally down-regulated protein 8; NEDD-8 (NEDD8)

General

protein conjugation

References

  1. Hemelaar J, Borodovsky A, Kessler BM, Reverter D et al Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins. Mol Cell Biol. 2004 Jan;24(1):84-95. PMID: 14673145