NEDD8; ubiquitin-like protein Nedd8; neddylin; neural cell expressed developmentally down-regulated protein 8; NEDD-8 (NEDD8)

Function: 1) ubiquitin-like protein 2) cell cycle control 3) embryogenesis 4) covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 & linkage to the E2 enzyme UBE2M 5) attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity 6) promotes polyubiquitination & proteasomal degradation of cyclins 7) directly interacts with NUB1, AHR 8) covalently attached to cullins, p53 9) cleavage of precursor form by UCHL3 or SENP8 is necessary for function Structure: belongs to the ubiquitin family Compartment: nucleus Expression: - expressed in heart, skeletal muscle, spleen, thymus, prostate, testis, ovary, colon, leukocytes

Related

amyloid beta precursor protein binding protein 1; NEDD8-activating enzyme E1 regulatory subunit; amyloid protein-binding protein 1; amyloid beta precursor protein-binding protein 1 59 kD; APP-binding protein 1; APP-BP1; protooncogene protein 1 (NAE1, HPP1, APPBP1) cullin-associated NEDD8-dissociated protein (CAND) NEDD8-activating enzyme E1 catalytic subunit; NEDD8-activating enzyme E1C; ubiquitin-activating enzyme E1C; ubiquitin-like modifier-activating enzyme 3; ubiquitin-activating enzyme 3 (UBA3, UBE1C) NEDD8-conjugating enzyme Ubc12; NEDD8 carrier protein; NEDD8 protein ligase; ubiquitin-conjugating enzyme E2 M (UBE2M, UBC12) neural precursor cell expressed developmentally downregulated (NEDD) protein

Properties

SIZE: entity length = 81 aa MW = 9 kD COMPARTMENT: cell nucleus MOTIF: leucine residue {8} isoleucine residue {44} UBE1C interaction {70-72}

Database Correlations

OMIM 603171 UniProt Q15843 Pfam PF00240 Entrez Gene 4738 Kegg hsa:4738

References

UniProt :accession Q15843