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NEDD1 protein; neural cell expressed developmentally down-regulated protein 1; NEDD-1 (NEDD1)
Function:
- embryonic development & differentiation of the central nervous system
- required for progression of mitosis
- promotes nucleation of microtubules from the spindle during mitosis
- prior phosphorylation on Thr-550 by CDK1 promotes subsequent phosphorylation by PLK1 on Thr-382, Ser-397, Ser-426 & Ser-637
- phosphorylated NEDD1 can interact with gamma-tubulin for targeting the gamma-tubulin ring complex (gTuRC) to the centrosome, a step in spindle formation
- interacts with FAM29A & gamma-tubulin
Structure: contains 8 WD repeats
Compartment: cytoplasm, cytoskeleton, centrosome
Alternative splicing: named isoforms=2
Related
neural precursor cell expressed developmentally downregulated (NEDD) protein
General
phosphoprotein
WD repeat protein family
Properties
SIZE: entity length = 660 aa
MW = 72 kD
COMPARTMENT: cytoplasm
MOTIF: WD repeat {1-31}
WD repeat {32-71}
WD repeat {75-114}
WD repeat {117-156}
WD repeat {160-200}
WD repeat {204-244}
WD repeat {246-285}
WD repeat {289-332}
Thr phosphorylation site {T382}
Ser phosphorylation site {S397}
Ser phosphorylation site {S411}
Ser phosphorylation site {S426}
Ser phosphorylation site {S516}
Thr phosphorylation site {T550}
Ser phosphorylation site {S574}
Ser phosphorylation site {S637}
Database Correlations
OMIM 600372
UniProt Q8NHV4
Pfam PF00400
Entrez Gene 121441
Kegg hsa:121441
References
UniProt :accession Q8NHV4