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necrosis
Death of tissue.
Etiology:
1) ischemia
2) hypoglycemia
3) infection
4) inflammation
Pathology:
1) swelling & rupture of cell
2) mitochochondria disintegrate
3) ATP is depleted
4) disintegration of other organelles
5) induction of inflammatory process
Notes: Necrosis contrasts with apoptosis by an early loss in membrane integrity, leakage of cytoplasmic contents & induction of the inflammatory process. Apoptosis is associated with changes in membrane permeability without membrane disinitegration & without induction of the inflammatory process. Necrosis is pathologic, whereas apoptosis can be pathologic or physiologic.
Necrosis may involve massive activation of poly ADP-ribose polymerase & depletion of NAD & secondarily ATP. [1]
Related
necrotic tissue
Specific
avascular necrosis (AVN)
caseous necrosis
coagulation necrosis
colonic necrosis
enzymatic fat necrosis
fibrinoid necrosis
gangrene
geographic necrosis
hepatic necrosis
liquefaction necrosis
myonecrosis
oncosis (ischemic cell death)
osteonecrosis
pancreatic necrosis
radiation necrosis
renal cortical necrosis
renal papillary necrosis
skin necrosis
General
death
References
- Sedlak TW, Snyder SH.
Messenger molecules and cell death: therapeutic implications.
JAMA. 2006 Jan 4;295(1):81-9.
PMID: 16391220
- Okada H, Mak TW.
Pathways of apoptotic and non-apoptotic death in tumour cells.
Nat Rev Cancer. 2004 Aug;4(8):592-603. Review. No abstract available.
PMID: 15286739
- Danial NN, Korsmeyer SJ.
Cell death: critical control points.
Cell. 2004 Jan 23;116(2):205-19. Review.
PMID: 14744432
- Syntichaki P, Tavernarakis N.
The biochemistry of neuronal necrosis: rogue biology?
Nat Rev Neurosci. 2003 Aug;4(8):672-84. Review. No abstract available.
PMID: 12894242
- Syntichaki P, Tavernarakis N.
Death by necrosis. Uncontrollable catastrophe, or is there
order behind the chaos?
EMBO Rep. 2002 Jul;3(7):604-9.
PMID: 12101090