necdin (NDN)

Function: 1) growth suppressor, facilitates entry into cell cycle arrest 2) functionally similar to Rb protein, binds to & represses activity of cell-cycle-promoting proteins & transcription factor E2F 3) interacts with p53 & works in an additive manner to inhibit cell growth 4) functions as transcription factor & binds directly to specific guanosine-rich DNA sequences 5) binds to the transactivation domains of E2F1 & p53. 6) interacts with nucleobindin 1 & nucleobindin 2 Structure: - contains 1 MAGE domain Compartment: - nucleus, neural perikarya - translocates to nucleus of postmitotic neurons & interacts with nuclear matrix Expression: - almost ubiquitous - expressed in fetal brain, lung, liver & kidney, in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon - not detected in peripheral blood leukocytes - in brain, restricted to post-mitotic neurons Pathology: - binds to & represses activity of cell-cycle-promoting proteins SV40 large T antigen, adenovirus E1A - defects in NDN may be a cause of the Prader-Willi syndrome

General

DNA-binding protein transcription factor (TF)

Properties

SIZE: MW = 36 kD entity length = 321 aa COMPARTMENT: cell nucleus MOTIF: DNA-binding motif melanoma-associated antigen (MAGE) domain {98-297}

Database Correlations

OMIM correlations UniProt Q99608 Pfam PF01454

References

UniProt :accession Q99608