NADH dehydrogenase B16.6 (NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13, complex 1-B16.6, C1-B16.6, gene associated with retinoic-interferon-induced mortality 19 protein, GRIM-19, cell death-regulatory protein, CGI-39, CDA016, NDUFA13)

Function: - accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex 1) - not involved in catalysis - involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death; this apoptotic activity is inhibited by interaction with viral IRF1 - prevents the transactivation of STAT3 target genes - may play a role in CARD15-mediated innate mucosal responses & serve to regulate intestinal epithelial cell responses to microbes - interacts with CARD15, but not with CARD4 - interacts with STAT3, but not with STAT1, STAT2 & STAT5A - interacts with HHV-8 IRF1, in the nucleus, with HPV-16 E6 & SV40 LT - interacts with OLFM4 Structure: belongs to the complex 1 NDUFA13 subunit family Compartment: - mitochondrial inner membrane, matrix side - nucleus - may be translocated into the nucleus upon IFN/RA treatment Expression: - widely expressed - highest expression in heart, skeletal muscle, liver, kidney & placenta - in intestinal mucosa, down-regulated in areas involved in Crohn's disease & ulcerative colitis - expressed in numerous fetal tissues - induced by interferon beta combined with all-trans-retinoic acid

Properties

SIZE: entity length = 144 aa MW = 17 kD COMPARTMENT: mitochondria cell nucleus MOTIF: transmembrane domain {30-51} Important for inducing cell death {102-144}

Database Correlations

UniProt Q9P0J0 Pfam PF06212

References

UniProt :accession Q9P0J0