NDC80 complex

Function: - required for chromosome segregation & spindle checkpoint activity - required for kinetochore integrity & organization of stable microtubule binding sites in the outer plate of the kinetochore Structure: - consists of: KNTC2/HEC1, CDCA1, SPBC24, SPBC25 - elongated rod-like structure with globular domains at either end

Properties

SUBUNITS: kinetochore protein Hec1 COMPARTMENT: cell nucleus MOTIF: binding site SITE: 1-445 FOR-BINDING-OF: Kinetochore protein Nuf2 MOTIF: nuclear localization {1-250} Ser phosphorylation site {S55} Ser phosphorylation site {S62} Ser phosphorylation site {S76} Ser phosphorylation site {S77} RB1 interaction {128-251} Ser phosphorylation site {S165} interaction with NEK2 & ZWINT {251-618} MOTIF: binding site SITE: 251-431 FOR-BINDING-OF: structural maintenance of chromosome 1-like 1 protein coiled coil {261-403} binding site SITE: 361-547 FOR-BINDING-OF: MSS1 protein structural maintenance of chromosome 1-like 1 protein binding site SITE: 446-642 FOR-BINDING-OF: testis-specific Y-encoded-like protein 2 MOTIF: coiled coil {458-642}

References

UniProt :accession O14777