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neuronal Ca+2 sensor 1; NCS-1; frequenin homolog; frequenin-like protein; frequenin-like ubiquitous protein (NCS1, FLUP, FREQ)
Function:
- neuronal calcium sensor
- regulates G protein-coupled receptor phosphorylation
- regulates GRK1
- may carry out functions similar to calmodulin
- interacts with KCND2
Cofactor: binds 3 Ca+2 ions
Compartment:
- associated with Golgi stacks
- found in:
a) post-synaptic densities of dendrites
b) pre-synaptic nerve terminal at neuromuscular junctions
General
Ca+2 sensor or Ca+2 sensing receptor
myristoylated protein
Properties
SIZE: entity length = 190 aa
MW = 22 kD
COMPARTMENT: cytoplasm
cell nucleus
golgi
MOTIF: myristoylation site
SITE: G2
EFFECTOR-BOUND: myristate
EF hand
SITE: 24-59
Ca+2-binding site
SITE: N-TERMINAL
cysteine-rich region {N-TERMINAL}
EF hand
SITE: 60-95
MOTIF: Ca+2-binding site
SITE: 73-84
membrane region
EF hand
SITE: 96-131
MOTIF: Ca+2-binding site
SITE: 109-120
EF hand
SITE: 144-179
MOTIF: Ca+2-binding site
SITE: 157-168
IL1RAPL1 interaction {174-190}
Database Correlations
OMIM 603315
UniProt P62166
Pfam PF00036
Entrez Gene 23413
Kegg hsa:23413
References
UniProt :accession P62166