natural cytotoxicity triggering receptor 3; activating natural killer receptor p30; natural killer cell p30-related protein; NK-p30; NKp30; CD337 (NCR3, 1C7, LY117)

Function: - cytotoxicity-activating receptor - may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis - interacts with CD3Z Structure: - belongs to the natural cytotoxicity receptor (NCR) family - contains 1 Ig-like (immunoglobulin-like) domain Compartment: - cell membrane; single-pass type 1 membrane protein (putative) Alternative splicing: named isoforms=6 Expression: - selectively expressed by all resting & activated NK cells - weakly expressed in spleen Polymorphism: - polymorphism in NCR3 is associated with mild suceptibility to malaria

General

cluster-of-differentiation antigen; cluster designation antigen; CD antigen natural cytotoxicity triggering receptor

Properties

SIZE: entity length = 201 aa MW = 22 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-18} immunoglobulin superfamily domain {19-126} MOTIF: cysteine residue {C39} MODIFICATION: cysteine residue {C108} N-glycosylation site {N42} cysteine residue {C108} MODIFICATION: cysteine residue {C39} N-glycosylation site {N121} transmembrane domain {136-156}

Database Correlations

OMIM correlations MORBIDMAP 611550 UniProt O14931 Pfam PF07686 Entrez Gene 259197 Kegg hsa:259197

References

UniProt :accession O14931