nuclear receptor corepressor 1 selections

nuclear receptor corepressor 1; N-CoR1; N-CoR (NCOR1 KIAA1047)

Function: - mediates transcriptional repression by certain nuclear receptors - interacts with unliganded nuclear receptors, including: RXR, RAR, T3R, & PPAR-alpha to keep them in a repressed state - part of a complex which promotes histone deacetylation & formation of repressive chromatin structures which may impede the access of basal transcription factors - ubiquitinated; mediated by SIAH2 & leading to its subsequent proteasomal degradation (putative) - interacts with SIAH2, HDAC7, SAP30, SIN3A & SIN3B - forms a large corepressor complex that contains SIN3A/B & histone deacetylases HDAC1 & HDAC2; this complex associates with the thyroid hormone receptor (erbA) & the retinoid acid receptors (RAR) in the absence of ligand - interacts with DACH1 - component of the N-cor repressor complex - interacts with TRIM28 & MJD2A/JHDM3A - interacts with ZBTB33/KAISO - interaction serves to recruit the N-CoR complex to promoter regions containing methylated CpG dinucleotides - interacts with the catalytic domain of HDAC9 - interacts with CBFA2T3 & HEXIM1 - interacts with C1D Structure: - the N-terminal region contains 3 independent domains capable of mediating transcriptional repression (RD1, RD2 & RD3) - the C-terminal region contains 2 separate nuclear receptor-interacting domains (ID1 & ID2), each of which contains a conserved sequence referred to as the CORNR box a) the CORNR box is necessary & sufficient for binding to unligated nuclear hormone receptors b) sequences flanking the CORNR box determine the precise nuclear hormone receptor specificity (putative) - belongs to the N-CoR nuclear receptor corepressors family - contains 2 SANT domains Compartment: nucleus (putative) Alternative splicing: named isoforms=2

General

nuclear receptor corepressor (N-COR) phosphoprotein

Properties

SIZE: entity length = 2440 aa MW = 270 kD COMPARTMENT: cell nucleus MOTIF: ZBTB33/HEXIM1 interaction {1-373} MOTIF: glutamine-rich region {58-64} MOTIF: glutamine residue (SEVERAL) Ser phosphorylation site {S157} Ser phosphorylation site {S158} Ser phosphorylation site {S172} coiled coil {174-216} Ser phosphorylation site {S224} SIN3A/B interaction {254-312} coiled coil {299-328} SANT 1 {435-486} coiled coil {501-557} alanine-rich region {593-603} MOTIF: alanine residue (SEVERAL) proline-rich region SITE: 607-617 MOTIF: proline residue (SEVERAL) SANT 2 {623-674} ETO interaction {988-1816} MOTIF: Ser phosphorylation site {S999} proline-rich region SITE: 1032-1035 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S1111} Ser phosphorylation site {S1450} Ser phosphorylation site {S1472} Tyr phosphorylation site {Y1476} Thr phosphorylation site {T1479} C1D interaction {1501-2440} MOTIF: alanine-rich region {1707-1712} MOTIF: alanine residue (SEVERAL) CORNR box 1 {1933-1937} serine-rich region {1952-1963} MOTIF: serine residue (SEVERAL) Ser phosphorylation site {S1977} Ser phosphorylation site {S1981} ID1 {2032-2115} CORNR box 2 {2055-2059} Ser phosphorylation site {S2102} Ser phosphorylation site {S2120} Ser phosphorylation site {S2151} Ser phosphorylation site {S2184} Ser phosphorylation site {S2202} ID2 {2212-2273} CORNR box 3 {2263-2267} Ser phosphorylation site {S2395} Thr phosphorylation site {T2399} Tyr phosphorylation site {Y2432} Thr phosphorylation site {T2434} Ser phosphorylation site {S2436} Ser phosphorylation site {S2438}

Database Correlations

OMIM 600849 UniProt O75376 Pfam PF00249 Entrez Gene 9611 Kegg hsa:9611

References

UniProt :accession O75376
Corton JC, Anderson SP, Stauber A. Central role of peroxisome proliferator-activated receptors in the actions of peroxisome proliferators. Annu Rev Pharmacol Toxicol. 2000;40:491-518. Review. PMID: 10836145

Component-of

N-cor repressor complex