nuclear receptor coactivator 7 (140 kD estrogen receptor-associated protein, estrogen nuclear receptor coactivator 1, NCOA7, ERAP140, ESNA1, Nbla00052, Nbla10993)

Function: - enhances transcriptional activities of several nuclear receptors - role in coactivation of different nuclear receptors, including: ESR1, THRB, PPARG & RARA - interacts with ESR1, ESR2A, ESR2B, THRB, PPARG & RARA (ligand-inducible) - interacts with heterodimer AHR-ARNT Structure: - belongs to the OXR1 family - contains 1 LysM repeat - contains 1 TLD domain Compartment: nucleus Alternative splicing: named isoforms=6 Expression: - highly expressed in brain - weakly expressed in mammary gland, ovary, uterus, prostate, stomach, bladder, spinal cord & pancreas Pathology: expressed in cancer cell line(s)

Properties

SIZE: MW = 106 kD entity length = 942 aa COMPARTMENT: cell nucleus MOTIF: coiled coil {4-29} LysM. {116-158} TLD {806-942}

Database Correlations

UniProt Q8NI08 PFAM correlations

References

UniProt :accession Q8NI08