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nuclear receptor coactivator 6; amplified in breast cancer protein 3; cancer-amplified transcriptional coactivator ASC-2; activating signal cointegrator 2; ASC-2; peroxisome proliferator-activated receptor-interacting protein; PPAR-interacting protein; PRIP; nuclear receptor-activating protein, 250 kDa; nuclear receptor coactivator RAP250; NRC RAP250; thyroid hormone receptor-binding protein (NCOA6, AIB3, KIAA0181, RAP250, TRBP)

Function: 1) directly binds nuclear receptors & stimulates hormone-dependent transcriptional activity 2) steroids (glucocorticoid receptor, estrogen receptor), 3) retinoids (RAR, RXR) 4) thyroid hormone receptor 5) vitamin D3 receptor 6) PPAR 7) general coactivator, NOT ONLY nuclear receptor coactivator 8) coactivation of the NF-kappa-B pathway 9) remodeling of chromatin 10) interaction with histone acetyltransferase 11) interacts with RNPC2, GTF2A, TBP, NCOA1, CRSP3, RBM14, EP300, CREBBP, NCOA6IP, PRMT2/HRMT1L1 12) phosphorylated by PRKDC 13) phosphorylation on Ser884 decreases binding to ESR1, ESR2 14) component of: ASC2/NCOA6 complex (ASCOM) Structure: - monomer, homodimer - contains two Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs - only motif 1 is essential for the association with nuclear receptors, while adjacent Ser-884 displays selectivity for nuclear receptors Compartment: nucleus Expression: - ubiquitous - highly expressed in brain, prostate, testis, ovary - weakly expressed in lung, thymus, small intestine Pathology: - frequently amplified or ovexpressed in colon cancer, breast cancer, lung cancers

Related

nuclear hormone receptor family

General

nuclear (steroid) receptor coactivator (NRC, SRC, NCoA) phosphoprotein

Properties

SIZE: entity length = 2063 aa MW = 219 kD COMPARTMENT: cell nucleus MOTIF: binding site SITE: 1-1310 FOR-BINDING-OF: nuclear receptor coactivator 1 MOTIF: binding site SITE: 1-1057 FOR-BINDING-OF: CREB-binding protein binding site SITE: 1-928 FOR-BINDING-OF: TBP/GTF2A glutamine-rich region {227-1041} MOTIF: glutamine residue (SEVERAL) proline-rich region SITE: 372-377 MOTIF: proline residue (SEVERAL) binding site SITE: 773-927 FOR-BINDING-OF: trimethylguanosine synthase Ser phosphorylation site {S884} LXXLL motif 1 {887-891} lysine-rich region {913-918} MOTIF: lysine residue (SEVERAL) Thr phosphorylation site {T1321} LXXLL motif 2 {1491-1495} binding site SITE: 1641-2063 FOR-BINDING-OF: EP300/CRSP3

Database Correlations

OMIM 605299 UniProt Q14686 Entrez Gene 23054 Kegg hsa:23054

References

  1. OMIM :accession 605299
  2. UniProt :accession Q14686

Component-of

MLL3/MLL4 complex