nuclear receptor coactivator 5; NCoA-5; coactivator independent of AF-2; CIA (NCOA5 KIAA1637)

Function: - nuclear receptor coregulator - can have both coactivator & corepressor functions - interacts with steroid receptors (ESR1 & ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, & with the orphan nuclear receptor NR1D2 - role in coactivation of nuclear steroid receptors (ER) as well as corepression of MYC in response to 17-beta-estradiol (E2) - binds HTATIP2/TIP30 - interacts with YLPM1 - forms a complex with ILF2, ILF3, YLPM1, KHDRBS1, RBMX & PPP1CA Structure: - contains one Leu-Xaa-Xaa-Leu-Leu (LxxLL) motif essential for association with nuclear receptors Compartment: nucleus Expression: widely expressed

General

nuclear (steroid) receptor coactivator (NRC, SRC, NCoA) phosphoprotein

Properties

SIZE: entity length = 579 aa MW = 66 kD COMPARTMENT: cell nucleus MOTIF: silencer element SITE: 1-158 acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Thr phosphorylation site {T3} Ser phosphorylation site {S9} Ser phosphorylation site {S29} Ser phosphorylation site {S34} Tyr phosphorylation site {Y127} Ser phosphorylation site {S151} LXXLL {345-349} Ser phosphorylation site {S377} Ser phosphorylation site {S378} Thr phosphorylation site {T379} Ser phosphorylation site {S381} Ser phosphorylation site {S387} Ser phosphorylation site {S404} Thr phosphorylation site {T420} transcriptional activation domain SITE: 458-579

Database Correlations

UniProt Q9HCD5 Entrez Gene 57727 Kegg hsa:57727

References

UniProt :accession Q9HCD5