Nck-associated protein 1; NAP 1; membrane-associated protein HEM-2; p125Nap1 (NCKAP1, HEM2, KIAA0587, NAP1)

Function: - part of lamellipodia complex that controls Rac-dependent actin remodeling (putative) - associates preferentially with the first SH3 domain of NCK - component of the WAVE2 complex - component of the WAVE1 complex Structure: belongs to the HEM-1/HEM-2 family Compartment: - cell membrane - single-pass membrane protein cytoplasmic side (putative) - cell projection, lamellipodia - at the interface between the lamellipodia actin meshwork & the membrane (putative) Alternative splicing: named isoforms=2 Expression: - expressed in most tissues - highest expression in brain, heart, & skeletal muscle - not expressed in peripheral blood leukocytes

Related

nck adaptor protein Nck-associated protein 1-like (membrane-associated protein HEM-1, hematopoietic protein 1, NCKAP1L, HEM1)

General

membrane protein Nck-associated protein (NAP)

Properties

SIZE: entity length = 1128 aa MW = 129 kD COMPARTMENT: cytoplasm MOTIF: transmembrane domain {995-1015}

Database Correlations

OMIM 604891 UniProt Q9Y2A7 Pfam PF09735 Entrez Gene 10787 Kegg hsa:10787

References

UniProt :accession Q9Y2A7