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p67phox; neutrophil cytosol factor-2; NCF-2; neutrophil NADPH oxidase factor
Function:
- NCF2, NCF1, & a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production)
Structure:
- contains 1 OPR domain
- contains 2 SH3 domains
- contains 3 TPR repeats
Compartment: cytoplasm
Pathology:
- defects in NCF2 are a cause of autosomal recessive chronic granulomatous disease
Interactions
molecular events
Related
chronic granulomatous disease
General
other protein
Properties
SIZE: MW = 67 kD
COMPARTMENT: cytoplasm
CELL: neutrophil
T-cell
B lymphocyte
MOTIF: src homology 3 [SH3] domain (2)
Database Correlations
OMIM 233710
UniProt P19878
References
- Rotrosen D, Yeung CL, Leto TL, Malech HL, Kwong CH.
Cytochrome b558: the flavin-binding component of the phagocyte
NADPH oxidase.
Science. 1992 Jun 5;256(5062):1459-62.
PMID: 1318579
- Segal AW, Abo A.
The biochemical basis of the NADPH oxidase of phagocytes.
Trends Biochem Sci. 1993 Feb;18(2):43-7. Review.
PMID: 8488557
- Pawson T
Protein modules and signalling networks
Nature 373:573 1995
PMID: 7531822
- NCF2base; NCF2 deficiency database
http://bioinf.uta.fi/NCF2base/
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=NCF2
- UniProt :accession P19878
Component-of
molecular complex