neurochondrin (NCDN KIAA0607)

Function: - probably involved in signal transduction in the nervous system - required for the spatial learning process but not for differentiation or neurite outgrowth of neurons - acts as a negative regulator of CaM kinase-2 phosphorylation - may play a role in modulating melanin-concentrating hormone- mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction - may be involved in bone metabolism - overexpression in neural cell lines leads to stimulated neurite outgrowth; however, relevance in vivo unclear - interacts with SEMA4C (putative) - interacts with MCHR1 Structure: belongs to the neurochondrin family Compartment: - cytoplasm, cell projection, dendrite - ocalizes to somatic regions of neurons Alternative splicing: named isoforms=3 Expression: - abundantly expressed in whole adult brain & in all individual brain regions examined, including spinal cord - weakly expressed in ovary, testis, & fetal brain

Properties

SIZE: entity length = 729 aa MW = 79 kD COMPARTMENT: cytoplasm MOTIF: Ser phosphorylation site {S50} Thr phosphorylation site {T60}

Database Correlations

OMIM 608458 UniProt Q9UBB6 Pfam PF05536 Kegg hsa:2315

References

UniProt :accession Q9UBB6