Search
80 kD nuclear cap binding protein (NCBP 80 kD subunit, nuclear cap-binding protein subunit 1, CBP80, NCBP1, NCBP)
Function:
1) role in mediating U snRNA export from the nucleus
2) binds to 5'capped mRNA
3) found in a U snRNA export complex with RNUXA/PHAX, CBP20, CBP80, RAN, XPO1 & m7G-capped RNA
4) interaction with RNUXA/PHAX (putative)
5) heterodimer with NCBP2
6) part of the exon junction complex
Structure:
- belongs to the NCBP1 family
- contains 1 MIF4G domain
Compartment: nucleus
Related
eukaryotic translation initiation factor 4E (eIF4E, mRNA cap-binding protein)
General
phosphoprotein
protein subunit
Properties
SIZE: entity length = 790 aa
MW = 92 kD
COMPARTMENT: cell nucleus
MOTIF: nuclear translocation signal {3-20}
Thr phosphorylation site {T21}
Ser phosphorylation site {S22}
MIF4G {28-240}
coiled coil {643-713}
MOTIF: Ser phosphorylation site {S674}
Database Correlations
OMIM 600469
UniProt Q09161
Pfam PF02854
References
UniProt :accession Q09161
Component-of
mRNP granule complex