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next to BRCA1 gene 1 protein (neighbor of BRCA1 gene 1 protein; membrane component, chromosome 17, surface marker 2; 1A1-3B; NBR1; 1A13B; KIAA0049; M17S2)
Function:
- interacts with SQSTM1, titin/TTN & RNF29
Structure:
- homooligomer & heterooligomer
- OPR domain mediates interaction with SQSTM1
- contains 1 OPR domain
- contains 1 UBA domain
- contains 1 ZZ-type zinc finger
Alternative splicing: named isoforms=2
General
zinc finger protein
Properties
SIZE: MW = 107 kD
entity length = 966 aa
MOTIF: OPR {43-71}
Zn finger ZZ-type
NAME: Zn finger ZZ-type
SITE: 211-257
EFFECTOR-BOUND: Zn+2
glutamate-rich region {703-714}
MOTIF: glutamate residue (SEVERAL)
UBA domain {913-957}
Database Correlations
OMIM 166945
UniProt Q14596
PFAM correlations
References
UniProt :accession Q14596