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homeobox protein NANOGP8
Function:
1) transcription regulator (putative)
2) when overexpressed, promotes cells to enter into S phase
Structure:
- almost identical to NANOG
- only one change in inferred amino acid sequence from 'Gln-253' in NANOG to His-253 in NANOGP8
- belongs to the Nanog homeobox family
- contains 1 homeobox DNA-binding domain
Compartment: nucleus
Expression:
- expressed in breast & urinary bladder tissues
Pathology:
- expressed in osteosarcoma, cervical cancer, hepatoma, & breast adenocarcinoma cancer cell lines
General
homeobox protein
Properties
SIZE: MW = 35 kD
entity length = 305 aa
COMPARTMENT: cell nucleus
MOTIF: homeodomain
SITE: 95-154
transactivation {196-240}
MOTIF: consensus repeat {196-200}
consensus repeat {201-205}
consensus repeat {206-210}
consensus repeat {216-220}
consensus repeat {221-225}
consensus repeat {226-230}
consensus repeat {231-235}
consensus repeat {236-240}
strong transactivation {241-305}
Database Correlations
UniProt Q6NSW7
Pfam PF00046
References
UniProt :accession Q6NSW7