Search
NACHT, LRR & PYD-containing protein 2; PYRIN domain & NACHT domain-containing protein 1; PYRIN-containing APAF1-like protein 2; nucleotide-binding site protein 1 (NALP2, NLRP2, NBS1, PAN1, PYPAF2)
Function:
1) suppresses TNF- & CD40-induced NFKB1 activity via IKK complex, by inhibiting NFKBIA degradation induced by TNF
2) when associated with PYCARD, activates CASP1, leading to secretion of mature proinflammatory cytokine IL1B
3) component of the inflammasome
4) interacts with CHUK, IKBKB & IKBKG,
5) interacts with PYCARD & DAPIN domain of NAPL1, but NOT full-length protein
6) DAPIN domain is necessary & sufficient for suppression of NFKB1 activation induced by TNF & for inducing IL1B secretion in association with caspase-1
- DAPIN domain is involved in interaction with PYCARD
7) isolated NACHT domain interacts with CARD8, but interaction not observed for full-length protein (autoinhibition?)
Structure:
- contains 1 DAPIN domain contains 9 LRR repeats (leucine-rich repeats) contains 1 NACHT domain
Compartment: cytoplasm
Alternative splicing: named isoforms=4
Expression:
- expressed in lung, placenta, thymus > ovary, intestine, brain
- induced by interferons & lipopolysaccharide (LPS)
General
NACHT, LRR & PYD-containing protein (NALP)
Properties
SIZE: MW = 121 kD
entity length = 1062 aa
COMPARTMENT: cytoplasm
MOTIF: DAPIN domain {1-94}
NACHT domain
NAME: NACHT domain
SITE: 207-526
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 213-220
leucine-rich repeat
SITE: 467-491
MOTIF: leucine residue (SEVERAL)
glutamate-rich region {518-523}
MOTIF: glutamate residue (SEVERAL)
leucine-rich repeat
SITE: 622-645
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 754-777
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 810-832
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 839-862
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 867-890
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 924-947
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 981-1005
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 1010-1033
MOTIF: leucine residue (SEVERAL)
Database Correlations
UniProt Q9NX02
PFAM correlations
References
UniProt :accession Q9NX02