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fenoprofen (Nalfon)
Tradename: Nalfon.
Dosage: 200-600 mg PO TID/QID, max 3200 mg/day.
Tabs: 200, 300, 600 mg.
Pharmacokinetics:
1) food decreases rate & extent of absorption
2) metabolized in liver to form 4-hydroxyfenoprofen glucuronide & fenoprofen glucuronide
Adverse effects:
1) gastrointestinal disturbance
2) rash
3) tinnitus
4) confusion
5) anorexia
6) leukopenia & thrombocytopenia (rare)
7) nephrotoxicity (uncommon)
8) hepatotoxicity (uncommon)
Drug interactions:
1) coadministration of aspirin decreases fenoprofen concentrations
2) probenecid may increase fenoprofen concentration
3) fenoprofen may increase plasma levels of:
a) digoxin
b) Li+
c) methotrexate
Laboratory:
1) specimen: serum, plasma (heparin, EDTA)
2) methods: GLC, HPLC
Interactions
drug interactions
drug adverse effects of NSAIDs
monitor with non steroidal anti-inflammatory agents (NSIADs)
General
non-steroidal anti-inflammatory agent (NSAID)
peroxisome proliferator; PPAR agonist; PPAR gamma agonist
Properties
INHIBITS: cyclooxygenase
MISC-INFO: elimination route LIVER
1/2life 2.5-3 HOURS
therapeutic-range 20-65 UG/ML
protein-binding 99%
elimination by hemodialysis -
peritoneal dialysis -
Database Correlations
PUBCHEM correlations
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Clinical Guide to Laboratory Tests, NW Tietz (ed) 3rd ed,
WB Saunders, Philadelpha 1995