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nanoparticle albumin-bound paclitaxel; Nab-paclitaxel (Abraxane)

Indications: - for use in combination with gemcitabine for treatment of pancreatic cancer [3] - metastatic breast cancer after failure (or contraindicaion) of anthracycline - for use in combination with carboplatin for treatment of locally advanced or metastatic non-small cell lung carcinoma Dosage: - injectable Adverse effects: - see paclitaxel Mechanism of action: - microtubule inhibitor

General

paclitaxel (Taxol)

References

  1. FDA News Release: Sept. 6, 2013 FDA approves Abraxane for late-stage pancreatic cancer. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm367442.htm
  2. Abraxane prescribing information http://www.abraxane.com/downloads/Abraxane_PrescribingInformation.pdf
  3. Von Hoff DD et al. Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. N Engl J Med 2013 PMID: 24131140 http://www.nejm.org/doi/full/10.1056/NEJMoa1304369