Na+/K+ ATPase-alpha 1 (Na+ pump subunit alpha-1, Na+/K+ ATPase alpha-1 subunit, ATP1A1)

Function: - catalytic component of the active enzyme, which catalyzes hydrolysis of ATP coupled with the exchange of Na⁺ & K⁺ ions across the plasma membrane - action creates the electrochemical gradient of Na⁺ & K⁺ ions, providing the energy for active transport of various nutrients - phosphorylation on Tyr-10 modulates pumping activity ATP + H₂O + Na⁺(in) + K⁺(out) ADP + phosphate + Na⁺(out) + K⁺(in) Structure: -belongs to the cation transport ATPase (P-type) family, type IIC subfamily Compartment: membrane, melanosome Alternative splicing: named isoforms=2 Expression: - predominant form in kidney - expressed in most tissues Genetics: Gene locus: 1p21 Note: - produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

General

Na+/K+ ATPase-alpha phosphoprotein transmembrane 10 protein

Properties

SIZE: entity length = 1023 aa MW = 113 kD MOTIF: cytoplasmic domain {6-87} MOTIF: Tyr phosphorylation site {Y10} Ser phosphorylation site {S16} Ser phosphorylation site {S47} Phosphoinositide-3 kinase binding {82-84} transmembrane domain {88-108} exoplasmic loop {109-131} transmembrane domain {132-152} cytoplasmic loop {153-288} MOTIF: Ser phosphorylation site {S217} Thr phosphorylation site {T219} Ser phosphorylation site {S228} transmembrane domain {289-308} exoplasmic loop {309-320} transmembrane domain {321-338} cytoplasmic loop {339-772} MOTIF: aspartate residue {D376} Ser phosphorylation site {S452} Mg+2-binding site SITE: 717-717 Mg+2-binding site SITE: 721-721 transmembrane domain {773-792} exoplasmic loop {793-802} transmembrane domain {803-823} cytoplasmic loop {824-843} transmembrane domain {844-866} exoplasmic loop {867-918} transmembrane domain {919-938} cytoplasmic loop {939-951} MOTIF: Ser phosphorylation site {S943} transmembrane domain {952-970} exoplasmic loop {971-985} transmembrane domain {986-1006} cytoplasmic domain {1007-1023}

Database Correlations

OMIM 182310 UniProt P05023 PFAM correlations Entrez Gene 476 ENZYME 3.6.3.9

References

OMIM :accession 182310