Contents

Search

Na+/K+ ATPase

Function: - catalytic component of the active enzyme, which catalyzes hydrolysis of ATP coupled with the exchange of Na+ & K+ ions across the plasma membrane - transports 3 Na+ out for 2 K+ in [3] - action creates the electrochemical gradient of Na+ & K+ ions, providing the energy for active transport of various nutrients ATP + H2O + Na+(in) + K+(out) ADP + phosphate + Na+(out) + K+(in) Structure: - composed of three subunits: alpha (catalytic), beta & gamma

Interactions

molecular events

General

E1-E2 ATPase or P-type ATPase electrogenic transporter multisubunit protein plasma membrane protein

Properties

COMPARTMENT: plasma membrane MOTIF: membrane region active site MOTIF: adenine nucleotide-binding site SUBUNITS: Na+/K+ ATPase-alpha MOTIF: membrane region active site MOTIF: ATP-binding site NAME: ATP-binding site Asp phosphorylation site Na+/K+ ATPase-beta MOTIF: transmembrane domain cysteine residue {X+0} MODIFICATION: cysteine residue {X+5} cysteine residue {X+5} MODIFICATION: cysteine residue {X+0} cysteine residue {X+7} MODIFICATION: cysteine residue {X+10} cysteine residue {X+10} MODIFICATION: cysteine residue {X+7} cysteine residue {X+18} MODIFICATION: cysteine residue {X+30} cysteine residue {X+30} MODIFICATION: cysteine residue {X+18} glycosylation site {C-TERMINAL} Na+/K+ ATPase-gamma MOTIF: transmembrane domain {29-46}

Database Correlations

OMIM 182310 ENZYME 3.6.1.3

References

  1. UI90203003
  2. OMIM :accession 182310
  3. Wikipedia: Bioelectrogenesis http://en.wikipedia.org/wiki/Bioelectrogenesis

Components

Na+/K+ ATPase-alpha Na+/K+ ATPase-beta Na+/K+ ATPase-gamma (FXYD domain-containing ion transport regulator 2, FXYD2, ATP1C, ATP1G1)