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N-type Ca+2 channel or neuronal-type Ca+2 channel
N for Neuronal Ca+2 channel. Responsible for voltage-activated release of neurotransmitter in many neurons.
Related
syntaxin-1A; syntaxin-A; neuron-specific antigen HPC-1 (STX1A, STX1)
General
voltage-dependent Ca+2 channel
Properties
COMPARTMENT: presynaptic membrane
CELL-REGION: axon terminal
CELL: neuron
MOTIF: membrane region
ion channel
COMPARTMENT: cellular membrane
MOTIF: membrane region
ION-PERMEABILITY: Ca+2
SUBUNITS: voltage-dependent Ca+2 channel alpha-1B
MOTIF: cytoplasmic domain {1-95}
transmembrane domain {96-114}
exoplasmic loop {115-132}
transmembrane domain {133-152}
cytoplasmic loop {153-163}
transmembrane domain {164-183}
exoplasmic loop {184-187}
transmembrane domain {188-206}
cytoplasmic loop {207-225}
transmembrane domain {226-245}
exoplasmic loop {246-331}
MOTIF: N-glycosylation site {N256}
transmembrane domain {332-356}
cytoplasmic loop {357-482}
MOTIF: binding to beta subunit {379-396}
ATP-binding site
NAME: ATP-binding site
SITE: 451-458
transmembrane domain {483-501}
exoplasmic loop {502-516}
transmembrane domain {517-536}
cytoplasmic loop {537-544}
transmembrane domain {545-562}
exoplasmic loop {563-573}
transmembrane domain {574-592}
cytoplasmic loop {593-611}
transmembrane domain {612-631}
exoplasmic loop {632-684}
transmembrane domain {685-709}
cytoplasmic loop {710-1151}
transmembrane domain {1152-1169}
exoplasmic loop {1170-1185}
transmembrane domain {1186-1205}
cytoplasmic loop {1206-1217}
transmembrane domain {1218-1236}
exoplasmic loop {1237-1246}
transmembrane domain {1247-1265}
cytoplasmic loop {1266-1284}
transmembrane domain {1285-1304}
exoplasmic loop {1305-1391}
transmembrane domain {1392-1416}
cytoplasmic loop {1417-1471}
transmembrane domain {1472-1490}
exoplasmic loop {1491-1505}
transmembrane domain {1506-1525}
cytoplasmic loop {1526-1533}
transmembrane domain {1534-1552}
exoplasmic loop {1553-1563}
MOTIF: N-glycosylation site {N1563}
transmembrane domain {1564-1582}
cytoplasmic loop {1583-1601}
transmembrane domain {1602-1621}
exoplasmic loop {1622-1683}
MOTIF: N-glycosylation site {N1675}
transmembrane domain {1684-1708}
cytoplasmic domain {1709-2339}
MOTIF: Ser phosphorylation site {S1719}
EF hand
SITE: 1724-1759
Ca+2-binding site
SITE: 1737-1748
Ser phosphorylation site {S1968}
histidine-rich region {2050-2054}
MOTIF: histidine residue (SEVERAL)
serine-rich region {2118-2122}
MOTIF: serine residue (SEVERAL)
Ser phosphorylation site {S2256}
voltage-dependent Ca+2 channel alpha-2/delta
MOTIF: membrane region
voltage-dependent L-type Ca+2 channel beta-3
MOTIF: src homology 3 [SH3] domain
SITE: 59-120
Tyr phosphorylation site {Y171}
voltage-dependent Ca+2 channel-gp95
MOTIF: N-glycosylation site
membrane region
MISC-INFO: Ki [OMEGA_CONOTOXIN] 0.08 NM
References
- Williams ME et al
Structure and functional expression of an omega-conotoxin-
sensitive human N-type calcium channel.
Science. 1992 Jul 17;257(5068):389-95.
PMID: 1321501
- Witcher DR et al
Subunit identification and reconstitution of the N-type
Ca2+ channel complex purified from brain.
Science. 1993 Jul 23;261(5120):486-9.
PMID: 8392754
Components
voltage-dependent Ca+2 channel alpha-1B (N type, L-type Cav2.2, CACNA1B, CACNL1A5, CACH51)
voltage-dependent Ca+2 channel alpha-2/delta
voltage-dependent Ca+2 channel-glycoprotein 95 [gp95]
voltage-dependent L-type Ca+2 channel beta-3; CAB3; Ca+2 channel voltage-dependent subunit beta 3 (CACNB3, CACNLB3)