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N-retinylidine-N-retinyl phosphatidyl ethanolamine
N-retinylidine-N-retinyl phosphatidyl ethanolamine is formed from reaction of phosphatidylethanolamine & retinaldehyde in disc membranes of photoreceptor outer segments. After the shed discs are phagocytosed by the retinal pigment epithelium, the molecule loses its phosphoglyceroid moiety to leave N-retinylidine-N-retinyl ethanolamine (the major component of lipofuscin in pigment epithelium).
Interactions
molecular events
Related
lipofuscin
N-retinylidine-N-retinyl ethanolamine
General
phosphatidylethanolamine; cephalin
retinoid
Schiff base (aldimine)
Properties
COMPARTMENT: plasma membrane
CELL-REGION: rod outer segment
CELL: rod
WITHIN: retina
References
- Eldred GE, Lasky MR.
Retinal age pigments generated by self-assembling
lysosomotropic detergents.
Nature. 1993 Feb 25;361(6414):724-6.
PMID: 8441466