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N-retinylidine-N-retinyl ethanolamine
N-retinylidine-N-retinylethanolamine is the major component of lipofuscin in pigment epithelium. It is formed from reaction of ethanolamine or phosphatidyl-ethanolamine with retinaldehyde in disc membranes of photoreceptor outer segments. After the shed discs are phagocytosed by the retinal pigment epithelium, the molecule loses its phosphoglyceroid moiety to leave N- retinylidine-N-retinyl ethanolamine. This amphoteric quaternary amine is precisely the type of compound predicted to accumulate within lysosomes.
Interactions
molecular events
Related
lipofuscin
N-retinylidine-N-retinyl phosphatidyl ethanolamine
General
retinoid
Schiff base (aldimine)
Properties
SIZE: MW = 592 G/M
COMPARTMENT: lysosome
CELL: epithelial cell
WITHIN: PIGMENT-EPTHELIUM
References
- Eldred GE, Lasky MR.
Retinal age pigments generated by self-assembling
lysosomotropic detergents.
Nature. 1993 Feb 25;361(6414):724-6.
PMID: 8441466