Search
N-cor repressor complex
Function:
- NCOR1 & ZBTB33 recruit the N-CoR complex to promoter regions containing methylated CpG dinucleotides
Structure:
- subunits include
- NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A & GPS2
General
molecular complex
transcriptional silencer (transcriptional repressor)
Properties
COMPARTMENT: cell nucleus
SUBUNITS: nuclear receptor corepressor 1
COMPARTMENT: cell nucleus
MOTIF: ZBTB33/HEXIM1 interaction {1-373}
MOTIF: glutamine-rich region {58-64}
MOTIF: glutamine residue (SEVERAL)
Ser phosphorylation site {S157}
Ser phosphorylation site {S158}
Ser phosphorylation site {S172}
coiled coil {174-216}
Ser phosphorylation site {S224}
SIN3A/B interaction {254-312}
coiled coil {299-328}
SANT 1 {435-486}
coiled coil {501-557}
alanine-rich region {593-603}
MOTIF: alanine residue (SEVERAL)
proline-rich region
SITE: 607-617
MOTIF: proline residue (SEVERAL)
SANT 2 {623-674}
ETO interaction {988-1816}
MOTIF: Ser phosphorylation site {S999}
proline-rich region
SITE: 1032-1035
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S1111}
Ser phosphorylation site {S1450}
Ser phosphorylation site {S1472}
Tyr phosphorylation site {Y1476}
Thr phosphorylation site {T1479}
C1D interaction {1501-2440}
MOTIF: alanine-rich region {1707-1712}
MOTIF: alanine residue (SEVERAL)
CORNR box 1 {1933-1937}
serine-rich region {1952-1963}
MOTIF: serine residue (SEVERAL)
Ser phosphorylation site {S1977}
Ser phosphorylation site {S1981}
ID1 {2032-2115}
CORNR box 2 {2055-2059}
Ser phosphorylation site {S2102}
Ser phosphorylation site {S2120}
Ser phosphorylation site {S2151}
Ser phosphorylation site {S2184}
Ser phosphorylation site {S2202}
ID2 {2212-2273}
CORNR box 3 {2263-2267}
Ser phosphorylation site {S2395}
Thr phosphorylation site {T2399}
Tyr phosphorylation site {Y2432}
Thr phosphorylation site {T2434}
Ser phosphorylation site {S2436}
Ser phosphorylation site {S2438}
nuclear receptor corepressor 2
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S54}
Ser phosphorylation site {S67}
Ser phosphorylation site {S149}
Ser phosphorylation site {S152}
Thr phosphorylation site {T156}
coiled coil {174-215}
MOTIF: Ser phosphorylation site {S215}
SIN3A/B interaction {254-312}
SANT 1 {427-478}
glutamine-rich region {494-510}
MOTIF: glutamine residue (SEVERAL)
coiled coil {522-561}
MOTIF: Thr phosphorylation site {T553}
Ser phosphorylation site {S554}
SANT 2 {610-661}
lysine-rich region {682-685}
MOTIF: lysine residue (SEVERAL)
Ser phosphorylation site {S745}
Ser phosphorylation site {S746}
Ser phosphorylation site {S750}
Ser phosphorylation site {S753}
proline-rich region
SITE: 778-820
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S864}
Ser phosphorylation site {S939}
Ser phosphorylation site {S956}
proline-rich region
SITE: 995-1003
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S1259}
Ser phosphorylation site {S1261}
Ser phosphorylation site {S1331}
Thr phosphorylation site {T1391}
proline-rich region
SITE: 1392-1397
MOTIF: proline residue (SEVERAL)
Thr phosphorylation site {T1444}
Ser phosphorylation site {S1487}
Ser phosphorylation site {S1584}
Ser phosphorylation site {S1786}
glycine-rich region {1850-1854}
Ser phosphorylation site {S1982}
Ser phosphorylation site {S2016}
Tyr phosphorylation site {Y2051}
Ser phosphorylation site {S2057}
Ser phosphorylation site {S2065}
Ser phosphorylation site {S2068}
Ser phosphorylation site {S2069}
Ser phosphorylation site {S2071}
Thr phosphorylation site {T2073}
CORNR box of ID1 {2147-2151}
Ser phosphorylation site {S2205}
Ser phosphorylation site {S2208}
Ser phosphorylation site {S2234}
Ser phosphorylation site {S2269}
CORNR box of ID2 {2350-2354}
Ser phosphorylation site {S2463}
proline-rich region
SITE: 2487-2490
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S2522}
Ser phosphorylation site {S2524}
histone deacetylase 3
COMPARTMENT: cell nucleus
MOTIF: Histone deacetylase {3-316}
MOTIF: histidine residue {H135}
F-box-like/WD repeat-containing protein TBL1X
COMPARTMENT: cell nucleus
MOTIF: LisH {55-87}
F-box domain {92-137}
alanine-rich region {159-175}
MOTIF: alanine residue (SEVERAL)
WD repeat {230-269}
WD repeat {286-325}
WD repeat {327-366}
WD repeat {369-409}
WD repeat {410-449}
WD repeat {452-500}
WD repeat {503-542}
WD repeat {544-576}
TBL1R
coronin-2A
MOTIF: WD repeat {80-120}
WD repeat {130-170}
WD repeat {178-217}
WD repeat {220-263}
WD repeat {269-308}
coiled coil {485-524}
G protein pathway suppressor 2
MOTIF: glutamate-rich region {32-35}
MOTIF: glutamate residue (SEVERAL)
References
UniProt :accession Q12800
Components
F-box-like/WD repeat-containing protein TBL1X; SMAP55; transducin beta-like protein 1X; transducin-beta-like protein 1, X-linked (TBL1X TBL1)
G protein pathway suppressor 2 (protein GPS2, GPS2)
histone deacetylase 3 (HDAC3, HD3, RPD3-2, SMAP45)
nuclear receptor corepressor 1; N-CoR1; N-CoR (NCOR1 KIAA1047)
nuclear receptor corepressor 2; N-CoR2; silencing mediator of retinoic acid & thyroid hormone receptor; SMRT; thyroid-, retinoic-acid-receptor-associated corepressor; T3 receptor-associating factor; TRAC; CTG repeat protein 26; SMAP270 (NCOR2, CTG26)
WD repeat-containing protein 2; coronin-2A; IR10 (CORO2A, IR10, WDR2)