N-acylglucosamine 2-epimerase; AGE; GlcNAc 2-epimerase; N-acetyl-D-glucosamine 2-epimerase; renin-binding protein; RnBP (RENBP)

Function: 1) N-acetylneuraminic acid biosynthesis 2) catalyzes interconversion of N-acetylglucosamine to N-acetylmannosamine 3) binds to renin forming a protein complex called HMW renin & inhibits renin activity N-acyl-D-glucosamine N-acyl-D-mannosamine. Structure: - homodimer - belongs to the N-acylglucosamine 2-epimerase family Alternative splicing: named isoforms=2 Note: - uncertain whether Met-1 or Met-11 is the initiator

Properties

SIZE: entity length = 427 aa MW = 49 kD MOTIF: leucine zipper SITE: 195-216 FOR-BINDING-VIA: leucine zipper active site

Database Correlations

OMIM 312420 UniProt P51606 Pfam PF07221 Entrez Gene 5973 KEGG correlations ENZYME 5.1.3.8

References

UniProt :accession P51606