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N5,N10-methylenetetrahydrofolate
Function:
- serine hydroxymethyltransferase catalyzes formation of 5,10-methylenetetrahydrofolate & glycine from serine & tetrahydrofolate
- the methylenetetrahydrofolate is, in turn used by:
a) thymidylate synthase in the biosynthesis of dTMP from dUMP#
b) 5,10 methylenetetrahydrofolate reductase to form N5-methyltetrahydrofolate*
* used by methionine synthase to regenerate methionine from homocysteine
# dihydrofolate results, with reduction by dihydrofolate reductase
Interactions
molecular events
Related
5,10-methylenetetrahydrofolate reductase (MTHFR)
folate metabolism
methionine metabolism (trans-sulfuration pathway)
serine hydroxymethyltransferase (SHMT), serine methylase or glycine hydroxymethyltransferase
thymidylate synthase; TS; TSase (TYMS, TS, OK/SW-cl29)
General
tetrahydrofolate (THF)
Database Correlations
PUBCHEM correlations