Search
myopalladin (145 kD sarcomeric protein, MYPN. MYOP)
Function:
1) component of the sarcomere
2) tethers together nebulin (skeletal muscle) & nebulette (cardiac muscle) to alpha-actinin, at the Z lines
3) interacts with titin, NEB, NEBL, ACTN2 & CARP
Structure:
- contains 5 Ig-like domains (immunoglobulin-like)
Compartment:
- cytoplasm, nucleus
- bound to sarcomere both at the Z-line periphery & in the central I-band region
Alternative splicing: named isoforms=3
Expression:
- expressed in adult skeletal muscle & fetal heart
General
phosphoprotein
Properties
SIZE: MW = 145 kD
entity length = 1320 aa
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: glycine-rich region {53-56}
coiled coil {219-248}
immunoglobulin superfamily domain {269-359}
MOTIF: cysteine residue {C290}
MODIFICATION: cysteine residue {C341}
cysteine residue {C341}
MODIFICATION: cysteine residue {C290}
immunoglobulin superfamily domain {435-531}
MOTIF: cysteine residue {C456}
MODIFICATION: cysteine residue {C515}
cysteine residue {C515}
MODIFICATION: cysteine residue {C456}
binding site
SITE: 649-677
FOR-BINDING-OF: nebulin
proline-rich region
SITE: 784-856
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S813}
Ser phosphorylation site {S818}
immunoglobulin superfamily domain {945-1029}
immunoglobulin superfamily domain {1073-1162}
MOTIF: cysteine residue {C1094}
MODIFICATION: cysteine residue {C1146}
cysteine residue {C1146}
MODIFICATION: cysteine residue {C1094}
immunoglobulin superfamily domain {1172-1262}
Database Correlations
OMIM 608517
UniProt Q86TC9
Pfam PF07679
References
UniProt :accession Q86TC9