myosin heavy chain 2; myosin heavy chain 2a; MyHC-2a; myosin heavy chain IIa; MyHC-IIa; myosin heavy chain, skeletal muscle, adult 2 (MYH2, MYHSA2)

Function: - muscle contraction - myosin heavy chain - required for cytoskeleton organization (putative) Structure: - muscle myosin is a hexameric protein that consists of a) 2 myosin heavy chain subunits b) 2 myosin essential light chain subunits c) 2 myosin regulatory light chain subunits - each myosin heavy chain can be split into 1 light meromyosin & 1 heavy meromyosin; it can later be split further into 2 globular subfragments (S1) & 1 rod-shaped subfragment (S2) - rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils - contains 1 IQ domain - contains 1 myosin head-like domain Compartment: - cytoplasm, myofibril - thick filaments of the myofibrils Expression: found in adult skeletal muscle. Pathology: - defects in MYH2 are the cause of inclusion body myopathy type 3

Related

myosin myosin II complex (GO:0016460)

Properties

CONFIGURATION: dimer SIZE: entity length = 1941 aa MW = 223 kD COMPARTMENT: cytoplasm MOTIF: Myosin head-like {1-786} MOTIF: ATP-binding site NAME: ATP-binding site SITE: 179-186 binding site SITE: 661-683 FOR-BINDING-OF: actin binding site SITE: 763-777 FOR-BINDING-OF: actin IQ motif {787-816} coiled coil {845-1941} P-loop FOR-BINDING-OF: adenosine triphosphate

Database Correlations

OMIM correlations MORBIDMAP 160740 UniProt Q9UKX2 PFAM correlations Entrez Gene 4620 Kegg hsa:4620

References

UniProt :accession Q9UKX2