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myogenic factor MYF-3; myoblast determination protein 1 (MYOD1, MYF3, MYOD)
Function:
- role in muscle differentiation (myogenic factor)
- induces fibroblasts to differentiate into myoblasts
- activates muscle-specific promoters
- interacts with & is inhibited by the twist protein; this interaction probably involves the basic domains of both proteins (putative)
- efficient DNA binding requires dimerization with another bHLH protein
- seems to form active heterodimers with ITF-2
- interacts with SUV39H1
- acetylated by a complex containing EP300 & PCAF
- acetylation is essential to activate target genes
- conversely, its deacetylation by SIRT1 inhibits its function (putative)
- ubiquitinated on the N-terminus; which is required for proteasomal degradation
Structure: contains 1 basic helix-loop-helix (bHLH) domain
Compartment: nucleus
Related
MyoD1 Ag in tissue
General
basic helix loop helix (bHLH) family transcription factor
Properties
SIZE: MW = 34 kD
entity length = 319 aa
COMPARTMENT: cell nucleus
MOTIF: DNA-binding motif
SITE: 109-121
helix-loop-helix
NAME: helix-loop-helix
SITE: 122-161
FOR-BINDING-VIA: helix-loop-helix
basic helix-loop-helix
MOTIF: basic DNA-binding motif
helix-loop-helix
NAME: helix-loop-helix
FOR-BINDING-VIA: helix-loop-helix
FOR-BINDING-OF: DNA motif
FOR-BINDING-VIA: helix-loop-helix
Database Correlations
OMIM 159970
UniProt P15172
PFAM correlations
References
- UniProt :accession P15172
- Wikipedia; Note: myoD entry
http://en.wikipedia.org/wiki/myoD