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myosin 9a; unconventional myosin-9a (MYO9A, MYR7)
Function:
- unconventional myosin
- regulates Rho activity in neurons
- role in the regulation of neuronal morphology & function (putative)
Structure:
- contains 5 IQ domains
- contains 2 myosin head-like domains
- contains 2 phorbol-ester/DAG-type Zn+2 fingers
- contains 1 Ras-associating domain
- contains 1 Rho-GAP domain
- lacks the ATP-binding domain which suggests that it cannot interact with actin
Compartment: membrane (putative)
Alternative splicing: named isoforms=5
Expression:
- expressed in testis & placenta, & at lower levels in all tissues examined tissues except liver
- isoform 5 was found in leukocytes but not in brain, retina or testis
Pathology: candidate gene for the Bardet-Biedl syndrome
General
membrane protein
unconventional myosin
zinc finger protein
Properties
SIZE: entity length = 2548 aa
MW = 293 kD
COMPARTMENT: cellular membrane
MOTIF: Ras-associating {14-112}
Myosin head-like 1 {148-690}
MOTIF: transmembrane domain {175-195}
ATP-binding site
NAME: ATP-binding site
SITE: 239-246
Myosin head-like 2 {884-1005}
MOTIF: binding site
SITE: 907-918
FOR-BINDING-OF: actin
Neck or regulatory {1021-1162}
MOTIF: IQ motif {1021-1041}
IQ motif {1042-1071}
IQ motif {1074-1103}
IQ motif {1115-1144}
IQ motif {1138-1167}
Tail {1163-2511}
MOTIF: coiled coil {1264-1291}
coiled coil {1486-1532}
Zinc finger
NAME: Zinc finger
SITE: 1999-2048
EFFECTOR-BOUND: Zn+2
rho-GAP domain
NAME: rho-GAP domain
SITE: 2063-2251
Zinc finger
NAME: Zinc finger
SITE: 2068-2119
EFFECTOR-BOUND: Zn+2
coiled coil {2315-2358}
Database Correlations
OMIM 604875
UniProt B2RTY4
References
UniProt :accession B2RTY4