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myosin-18a; molecule associated with JAK3 N-terminus; MAJN; myosin containing a PDZ domain (MYO18A, KIAA0216 MYSPDZ)
Function:
- may be involved in the maintenance of the stromal cell architectures required for cell to cell contact (putative)
- interacts with JAK3 & actin
Structure:
- homodimer
- contains 1 IQ domain
- contains 1 myosin head-like domain
- contains 1 PDZ domain (DHR domain)
- isoform 2 lacks the PDZ domain
Compartment:
- isoform 1:
- endoplasmic reticulum-Golgi intermediate compartment (putative)
- cytoplasm, cytoskeleton
- colocalizes with actin
- isoform 2: diffusely localized in the cytoplasm
Alternative splicing: named isoforms=5
Note:
- TIAF1 protein is coded in the 3'-UTR region of MYO18A gene
General
phosphoprotein
unconventional myosin
Properties
SIZE: entity length = 2054 aa
MW = 233 kD
COMPARTMENT: cytoplasm
golgi
endoplasmic reticulum
MOTIF: Ser phosphorylation site {S72}
Ser phosphorylation site {S74}
Ser phosphorylation site {S83}
Ser phosphorylation site {S102}
Interaction with actin {114-118}
Ser phosphorylation site {S140}
Ser phosphorylation site {S164}
PDZ domain
NAME: PDZ domain
SITE: 220-311
MOTIF: Ser phosphorylation site {S234}
Myosin head-like {420-1186}
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 498-505
Ser phosphorylation site {S1039}
Ser phosphorylation site {S1063}
Ser phosphorylation site {S1067}
Ser phosphorylation site {S1070}
IQ motif {1188-1217}
coiled coil {1246-1971}
MOTIF: Ser phosphorylation site {S1942}
Ser phosphorylation site {S1951}
Ser phosphorylation site {S1970}
Ser phosphorylation site {S1974}
Ser phosphorylation site {S1998}
Ser phosphorylation site {S2002}
Ser phosphorylation site {S2007}
Ser phosphorylation site {S2020}
Ser phosphorylation site {S2036}
Ser phosphorylation site {S2041}
Ser phosphorylation site {S2043}
Thr phosphorylation site {T2045}
Database Correlations
OMIM correlations
UniProt Q92614
PFAM correlations
Entrez Gene 399687
Kegg hsa:399687
References
UniProt :accession Q92614