myosin-15; unconventional myosin-15 (MYO15A, MYO15)

Function: - myosins are actin-based motor molecules with ATPase activity - unconventional myosins serve in intracellular movements - their highly divergent tails are presumed to bind to membrane compartments, which would be moved relative to actin filaments - required for the arrangement of stereocilia in mature hair bundles - interacts with the third PDZ domain of WHRN which is necessary for localization of WHRN to stereocilium tips - interacts with FASLG Structure: - contains 1 FERM domain - contains 3 IQ domains - contains 1 myosin head-like domain - contains 2 MyTH4 domains - contains 1 SH3 domain Compartment: - cell projection, stereocilium - cytoplasm, cytoskeleton (putative) - localizes to stereocilium tips in cochlear & vestibular hair cells (putative) Expression: - highly expressed in pituitary - also expressed at lower levels in adult brain, kidney, liver, lung, pancreas, placenta & skeletal muscle - not expressed in brain - highly expressed in anterior pituitary cells Pathology: - defects in MYO15A are the cause of autosomal recessive neurosensory deafness 3

Properties

SIZE: entity length = 3530 aa MW = 395 kD COMPARTMENT: cytoplasm MOTIF: Myosin head-like {1-1887} MOTIF: ATP-binding site NAME: ATP-binding site SITE: 1315-1322 coiled coil {1323-1350} actin-binding site SITE: 1792-1799 FOR-BINDING-OF: F-actin active site MOTIF: adenine nucleotide-binding site Neck or regulatory {1888-2029} MOTIF: IQ motif {1902-1924} IQ motif {1925-1954} IQ motif {1955-1976} Tail {2030-3530} MOTIF: MyTH4 1 {2065-2217} src homology 3 [SH3] domain SITE: 2867-2953 MyTH4 2 {3050-3204} FERM domain NAME: FERM domain SITE: 3209-3530

Database Correlations

OMIM correlations MORBIDMAP 602666 UniProt Q9UKN7 PFAM correlations Entrez Gene 51168 Kegg hsa:51168

References

UniProt :accession Q9UKN7