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myelophthisic anemia
Pathology:
- bone marrow failure secondary to infiltration by non-hematopoietic cells or pathogens
- destruction of hematopoietic precursor cells, often associated with marrow fibrosis
Etiology:
- metastatic carcinoma
- lymphoproliferative malignancies
- disseminated granulomatous disease
- inherited disorders (Gaucher disease)
Clinical manifestations:
- anemia
- thrombocytopenia
- neutropenia
Laboratory:
- nucleated red cells, teardrop forms
- giant platelets
- immature myeloid cells in peripheral smear
Interactions
disease interactions
General
hypoplastic anemia